![]() ![]() These different homeostatic processes have distinct effects on homeostatic synaptic plasticity and animal behavior. By contrast, expression of these genes remains unchanged in animals harboring a CRISPR-engineered, Shal pore-blocking mutation where compensation is achieved by enhanced IK DR. Eliminating Shal protein invokes Krüppel-dependent rebalancing of ion channel gene expression including enhanced slo, Shab, and Shaker. However, the underlying homeostatic signaling mechanisms are distinct. ![]() In agreement, we demonstrate robust FRH following either elimination of Kv4/Shal protein or elimination of the Kv4/Shal conductance. A prediction is that ion channel gene mutations with equivalent effects on neuronal excitability should invoke the same homeostatic response. ![]() A pervasive and intuitive theory argues that a single variable, calcium, is detected and stabilized through regulatory feedback. Firing rate homeostasis (FRH) stabilizes neural activity.
0 Comments
Leave a Reply. |